abstract：OBJECTIVE:The distinction between benign and malignant well-differentiated endocrine tumours is hard to achieve. The aim of the present study was to determine whether detection of telomerase or quantification of human telomerase reverse transcriptase protein subunit (hTERT) differ between benign and malignant endocrine...

journal_title：Clinical endocrinology

authors： Vezzosi D,Bouisson M,Escourrou G,Laurell H,Selves J,Seguin P,Pradayrol L,Caron P,Buscail L

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:We investigated the clinical usefulness of thyroid blood-flow measurement in predicting relapse of Graves' disease (GD) in comparison with known risk factors for GD relapse. MEASUREMENT:Thyroid blood flow was measured in pulsed Doppler mode at the inferior thyroid artery (ITA), and the peak systolic velocity...

journal_title：Clinical endocrinology

authors： Ueda M,Inaba M,Kumeda Y,Nagasaki T,Hiura Y,Tahara H,Onoda N,Ishikawa T,Nishizawa Y

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Assessment of the hypothalamic-pituitary-adrenal (HPA) axis after pituitary surgery is important for appropriate decision making regarding replacement therapy. The synacthen test is often used but is questioned, as time has to elapse for adrenal atrophy to develop. OBJECTIVE:To audit the use of the 250 micr...

journal_title：Clinical endocrinology

authors： Klose M,Lange M,Kosteljanetz M,Poulsgaard L,Feldt-Rasmussen U

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Milk-alkali syndrome, once a common cause of hypercalcaemia, is now considered rare. Our aim was to estimate the prevalence of milk-alkali syndrome among hypercalcaemic, non-end-stage renal disease (non-ESRD) inpatients of a University Hospital and identify patients' and syndrome characteristics. DESIGN AND ...

journal_title：Clinical endocrinology

authors： Picolos MK,Lavis VR,Orlander PR

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:The role of androgen decline in the sexual activity of adult males is controversial. To clarify whether sexual function would benefit from testosterone (T) treatment in men with partially or severely reduced serum T levels, we conducted a systematic review and meta-analysis of placebo-controlled studies publ...

journal_title：Clinical endocrinology

authors： Isidori AM,Giannetta E,Gianfrilli D,Greco EA,Bonifacio V,Aversa A,Isidori A,Fabbri A,Lenzi A

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Genetic alterations in four oncogenes, namely RAS point mutations, RET rearrangements (RET/PTC), NTRK1 rearrangements (TRK) and BRAF point mutations have been identified in human papillary thyroid carcinomas (PTCs). These oncogenes act along the RET/PTC(TRK)-RAS-BRAF-MEK-MAPK kinase pathway, mediating a numbe...

journal_title：Clinical endocrinology

authors： Liu RT,Chen YJ,Chou FF,Li CL,Wu WL,Tsai PC,Huang CC,Cheng JT

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Obesity is a major risk factor for coronary heart disease, and surgical treatment of obese patients as part of a multidisciplinary approach seems to provide faster results than diet therapy. The aim of this study was to evaluate the effect of dermolipectomy on insulin action and inflammatory markers in 20 obe...

journal_title：Clinical endocrinology

authors： Rizzo MR,Paolisso G,Grella R,Barbieri M,Grella E,Ragno E,Grella R,Nicoletti G,D'Andrea F

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:The LMNA 1908C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome, adipose tissue metabolism and obesity phenotypes, suggesting that this polymorphism presents an increased risk of atherosclerosis and vascular diseases. However, there have been no previous reports on the ...

journal_title：Clinical endocrinology

authors： Liang H,Murase Y,Katuta Y,Asano A,Kobayashi J,Mabuchi H

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:Somatostatin analogues have become the mainstay of the medical treatment of acromegaly. The aim of our study was to evaluate the efficacy and tolerability of octreotide-LAR (OCT-LAR) treatment in acromegalic patients. DESIGN:Prospective open trial. PATIENTS AND METHODS:Eighty acromegalic patients (46 women;...

journal_title：Clinical endocrinology

authors： Jallad RS,Musolino NR,Salgado LR,Bronstein MD

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:In order to investigate whether somatotrophs are the target of antipituitary antibodies (APA) in adult patients with growth hormone deficiency (GHD), we studied the sera of 37 APA positive patients. PATIENTS:Patients were grouped as follows: nine patients with APA at high titre (> 1 : 8) affected by apparent...

journal_title：Clinical endocrinology

authors： De Bellis A,Bizzarro A,Perrino S,Coronella C,Conte M,Pasquali D,Sinisi AA,Betterle C,Bellastella A

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary (GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pitui...

journal_title：Clinical endocrinology

authors： Fuller PJ,Alexiadis M,Jobling T,McNeilage J

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:The mechanisms leading to higher bone mineral density (BMD) in hirsute patients than in healthy controls have seldom been examined. We compared the metabolic, hormonal and bone metabolic parameters in hirsute patients and female controls and correlated BMD and bone metabolic parameters with testosterone, oest...

journal_title：Clinical endocrinology

authors： Glintborg D,Andersen M,Hagen C,Hermann AP

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Traumatic brain injury (TBI) has been associated with hypopituitarism and GH deficiency. However, TBI-mediated hypopituitarism may be more frequent than previously thought. The present work, performed in patients with severe TBI at least 1 year before, had three aims: (i) to evaluate the prevalence of hypopit...

journal_title：Clinical endocrinology

authors： Leal-Cerro A,Flores JM,Rincon M,Murillo F,Pujol M,Garcia-Pesquera F,Dieguez C,Casanueva FF

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Acromegalic patients have increased left ventricular (LV) mass (M) and impaired diastolic function. AIM:Using ultrasonic cardiac tissue characterization, we evaluated the early changes in cardiac fibrosis (IBS) and intrinsic myocardial contractility (CVI) as well as their reversibility after treatment with ...

journal_title：Clinical endocrinology

authors： Bogazzi F,Di Bello V,Palagi C,Donne MG,Di Cori A,Gavioli S,Talini E,Cosci C,Sardella C,Brogioni S,Mariani M,Martino E

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:Correction of GH and IGF-I levels are associated with improvements in insulin secretion, cardiac performance and body composition in patients with acromegaly, but whether these parallel post-treatment levels of GH-IGF-I axis activity is undefined. We investigate whether various biochemical outcomes after tran...

journal_title：Clinical endocrinology

authors： Damjanovic SS,Neskovic AN,Petakov MS,Popovic V,Macut D,Vukojevic P,Joksimovic MM

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. DESIGN AND PATIENTS:Cross-sectional and longitudinal observational assessment of thyroid function in 420 adult females with type 2 diabetes randomly selected from participants in the community-based Fremantl...

journal_title：Clinical endocrinology

authors： Chubb SA,Davis WA,Inman Z,Davis TM

更新日期：2005-04-01 00:00:00

abstract：DESIGN:Prevalence of type 2 diabetes and glucose intolerance increase with age. It has been demonstrated that beta cell function declines at about 1% per year in glucose tolerant Caucasians. However, this relationship is not known to exist in other ethnic groups. SUBJECTS AND MEASUREMENTS:We investigated the relations...

journal_title：Clinical endocrinology

authors： Chiu KC,Martinez DS,Chu A

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:A functional polymorphism at codon 55 of the small ubiquitin-like modifier-4 (SUMO4) gene (methionine to valine; M55V) has recently been associated with type 1 diabetes mellitus (T1D). We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves' disease (GD) and auto...

journal_title：Clinical endocrinology

authors： Jennings CE,Owen CJ,Wilson V,Pearce SH

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:The incidence of thyroid cancer is increasing in several countries. The aim was to investigate trends in the incidence and mortality of thyroid cancer in Scotland, where thyroid cancer is relatively uncommon, between 1960 and 2002. DESIGN:Descriptive epidemiological study. METHODS:Thyroid cancer registratio...

journal_title：Clinical endocrinology

authors： Reynolds RM,Weir J,Stockton DL,Brewster DH,Sandeep TC,Strachan MW

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:The disruption between the brain and the spinal cord leads to a decentralized sympathetic nervous system in people with chronic, cervical spinal cord lesions. These tetraplegic subjects are prone to disorders of energy metabolism and osteoporosis, and they experience alterations in their body composition with...

journal_title：Clinical endocrinology

authors： Hjeltnes N,De Groot P,Birkeland KI,Falch JA,Iversen PO

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Women with previous gestational diabetes (pGDM) are at risk of developing Type 2 diabetes. Glucagon-like peptide-1 (GLP-1) potentiates the insulin response to oral glucose, and its secretion is diminished in Type 2 diabetes. The aim of the study was to see if decreased GLP-1 secretion might be ...

journal_title：Clinical endocrinology

authors： Forbes S,Moonan M,Robinson S,Anyaoku V,Patterson M,Murphy KG,Ghatei MA,Bloom SR,Johnston DG

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The intravenous low-dose ACTH test has been proposed as a sensitive tool to assess adrenal function through circulating steroids. The aims of this study were to: (a) find the minimal intramuscular ACTH dose that induced serum and salivary cortisol and aldosterone responses equivalent to those obtained after a...

journal_title：Clinical endocrinology

authors： Contreras LN,Arregger AL,Persi GG,Gonzalez NS,Cardoso EM

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The rarity of pituitary apoplexy renders it a difficult subject for audit; hence there are no evidence-based standards of optimum care for such patients. The key controversy in management relates to the role of acute neurosurgical intervention. In recent years we have adopted a relatively conse...

journal_title：Clinical endocrinology

authors： Ayuk J,McGregor EJ,Mitchell RD,Gittoes NJ

更新日期：2004-12-01 00:00:00

abstract：:Lactation has been associated with suppression of some components of the neuroendocrine stress response. In humans, suppression of the hypothalamo-pituitary-adrenal (HPA) axis has been demonstrated in response to both a psychological and an exercise challenge, but appears to be limited to a short period of time follow...

journal_title：Clinical endocrinology

authors： Kaye J,Soothill P,Hunt M,Lightman S

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:In adults, excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed children. The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of GH-deficient children tre...

journal_title：Clinical endocrinology

authors： Radetti G,Pasquino B,Gottardi E,Contadin IB,Rigon F,Aimaretti G

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA). DESIGN:Cross-sectional,...

journal_title：Clinical endocrinology

authors： López-Bermejo A,Casano-Sancho P,Fernández-Real JM,Kihara S,Funahashi T,Rodríguez-Hierro F,Ricart W,Ibañez L

更新日期：2004-09-01 00:00:00

abstract：:Recombinant human TSH (rhTSH) has revolutionized the care of patients with differentiated thyroid cancer. Since its approval for clinical use in 2001 in Europe (1998 in the USA), rhTSH has greatly enhanced the surveillance of these patients by allowing the avoidance of hypothyroidism for TSH stimulation. Previously, a...

journal_title：Clinical endocrinology

authors： Woodmansee WW,Haugen BR

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:Recently, a somatic point mutation of the BRAF gene (V599E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (about 25-70%) in different series from USA, Japan, Portugal and Ukraine. DESIGN:In the present study, the genetic analysis of BRAF i...

journal_title：Clinical endocrinology

authors： Fugazzola L,Mannavola D,Cirello V,Vannucchi G,Muzza M,Vicentini L,Beck-Peccoz P

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Postsurgical regrowth or recurrence of nonfunctioning pituitary adenomas (NFAs) is not uncommon and often requires further surgery or radiotherapy (DXT). Routine postoperative DXT increases the incidence of hypopituitarism, which is associated with increased morbidity and mortality. Identification of genetic...

journal_title：Clinical endocrinology

authors： Buch HN,Raskauskiene D,Bahar A,Bicknell EJ,Farrell WE,Clayton RN

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is characterized by high androgen levels, ambiguous genitalia or premature pubarche, increased height velocity and skeletal maturation. Considering the possibility of changes in the IGF system components depending on the state of c...

journal_title：Clinical endocrinology

authors： Cunha HM,Elias LL,Camacho-Hübner C,Moreira AC,Martinelli CE Jr

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children. PATIENTS:One hundred and two boys, 13.6-15.5 years of age, who were referred because of short stature and delayed puberty. METHODS:The boys were randomly allocated to one of the following treatmen...

journal_title：Clinical endocrinology

authors： Zadik Z,Sinai T,Zung A,Reifen R

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:There is evidence from recent controlled clinical studies that replacement therapy of hypothyroidism with T4 in combination with a small amount of T3 may improve the well-being of the patients. As the issue is still the subject of controversial discussion, our study was assigned to confirm the superiority of...

journal_title：Clinical endocrinology

authors： Siegmund W,Spieker K,Weike AI,Giessmann T,Modess C,Dabers T,Kirsch G,Sänger E,Engel G,Hamm AO,Nauck M,Meng W

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Hypopituitarism, in particular GH deficiency, is prevalent in patients with clinically nonfunctioning pituitary adenomas (NFPAs) both before and after surgery. The factors regulating the growth of pituitary adenomas in general and residual tumour tissue in particular are not fully characterized, an...

journal_title：Clinical endocrinology

authors： Clausen LR,Kristiansen MT,Rasmussen LM,Billestrup N,Blaabjerg O,Ledet T,Jørgensen JO

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To determine the interest of Chromogranin A (CgA) determination for diagnosis and follow-up in patients with gastroenteropancreatic endocrine tumours (GEP-ET) and multiple endocrine neoplasia type 1 (MEN-1). PATIENTS AND METHODS:CgA levels were measured with an immunoradiometric assay in 124 sporadic GEP-ET,...

journal_title：Clinical endocrinology

authors： Nehar D,Lombard-Bohas C,Olivieri S,Claustrat B,Chayvialle JA,Penes MC,Sassolas G,Borson-Chazot F

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To compare the outcome of different treatment options used in several cases of non-islet cell tumour hypoglycaemia (NICTH). PATIENTS:Eight cases of NICTH were referred for diagnosis and monitoring following either surgical or medical treatment. METHODS:Serum samples collected throughout the time-course of e...

journal_title：Clinical endocrinology

authors： Teale JD,Wark G

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in acromegaly. Left ventricular mass (LVM) is an important parameter measured to detect LVH, but the relationship with body size should be considered by correcting LVM to body surface area (BSA), height or height2.7. All trials concern...

journal_title：Clinical endocrinology

authors： Vitale G,Galderisi M,Pivonello R,Spinelli L,Ciccarelli A,de Divitiis O,Lombardi G,Colao A

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:Vasopressin (AVP) is reported to be an important factor for regulating cortisol secretion in patients with Cushing's syndrome due to ACTH-independent macronodular adrenocortical hyperplasia (AIMAH). Recently, there have been several case reports of subclinical Cushing's syndrome due to AIMAH, in which the pat...

journal_title：Clinical endocrinology

authors： Tatsuno I,Uchida D,Tanaka T,Koide H,Shigeta A,Ichikawa T,Sasano H,Saito Y

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Cushing's syndrome (CS) is a well recognized cause of bone loss. Although many previous studies have shown decreased bone mineral density (BMD) in the lumbar spina and proximal femur of patients with endogenous CS, so far, the data estimating BMD in their peripheral skeleton are sparse. The aim of the present...

journal_title：Clinical endocrinology

authors： Karavitaki N,Ioannidis G,Giannakopoulos F,Mavrokefalos P,Thalassinos N

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In polycystic ovary syndrome (PCOS) inappropriate gonadotrophin secretion is characterized by increased pulse frequency and amplitude, elevated 24-h mean serum concentrations, and greater responses to GnRH. While the mechanism(s) responsible for this increased release of LH are not well underst...

journal_title：Clinical endocrinology

authors： Patel K,Coffler MS,Dahan MH,Malcom PJ,Deutsch R,Chang RJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The development of hepatocellular carcinoma in liver cirrhosis is associated with altered synthesis and secretion of several growth factors. AIM:The aim of this prospective study was to investigate the potential implication of IGF-I and its major binding protein (IGFBP-3) in the development of hepatocellula...

journal_title：Clinical endocrinology

authors： Mattera D,Capuano G,Colao A,Pivonello R,Manguso F,Puzziello A,D'Agostino L

更新日期：2003-12-01 00:00:00